Our research focuses on understanding how transcription–replication conflicts contribute to DNA replication stress and genome instability. These processes are fundamental drivers of cellular dysfunction and are strongly implicated in cancer development and treatment responses. We are particularly interested in how cells detect, resolve, or exploit these conflicts, and how these pathways can be targeted for therapeutic benefit. To address these questions, we combine high-resolution sequencing approaches with high-content imaging to map genome dynamics with exceptional precision. By integrating these technologies, we aim to uncover the molecular mechanisms that safeguard genome integrity and identify vulnerabilities that can be leveraged in cancer therapy.
